General Information

  • ID:  hor001124
  • Uniprot ID:  A0A401NN52??42-45)
  • Protein name:  FMRFamide
  • Gene name:  NA
  • Organism:  Scyliorhinus torazame (Cloudy catshark)
  • Family:  SMC family, SMC1 subfamily
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Scyliorhinus (genus), Scyliorhinidae (family), Carcharhiniformes (order), Galeoidea (superorder), Galeomorphii, Selachii (infraclass), Elasmobranchii (subclass), Chondrichthyes (class), Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005524 ATP binding; GO:0016887 ATP hydrolysis activity
  • GO BP:  GO:0007049 cell cycle; GO:0007062 sister chromatid cohesion; GO:0051276 chromosome organization
  • GO CC:  GO:0005634 nucleus; GO:0005694 chromosome; GO:0008278 cohesin complex

Sequence Information

  • Sequence:  FMRF
  • Length:  4(42-45)
  • Propeptide:  VEYIAVRSHLPPKHQVLGMGTLQLIQVENFKSWRGRQLIGPFMRFNCIIGPNGSGKSNVMDAISFVMGERTACLRVKHIKDLIHGAHIGYPVSSTARVTMLYETENGEELSFTRAIIGNSSEFRLNDRTVSRVEYTNELEKIGILLKGRNCLVFQGAVENIAMKKPKERTQLFEQVSNSGELSNEYDKKKKEMMNAEEEARFNYNKKKNVAVERKHAKHEKEEADRYQMLIEELKASRAQLHLFLLYYNEKLIEN
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-A0A401NN52-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor001124_AF2.pdbhor001124_ESM.pdb

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Physical Information

Mass: 65343 Formula: C29H41N7O5S
Absent amino acids: ACDEGHIKLNPQSTVWY Common amino acids: F
pI: 10.55 Basic residues: 1
Polar residues: 0 Hydrophobic residues: 2
Hydrophobicity: 75 Boman Index: -661
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 0
Instability Index: -1135 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  1682050
  • Title:  Immunocytochemical Distribution of FMRFamide-like Substance in the Brain of the Cloudy Dogfish, Scyliorhinus Torazame